•  
•  
•     The Pages:
•          
• Start
•          
• An Introduction
•          
• LHON Mutations
•          
• A Hypothesis
•          
• Computer Model
•          
• Scientific Papers
•          
• History
•          
• Basic Biology
•          
• Complex I
•          
• Links
•          
• Contact

                                   A

                              Guide to  

                          the Genetics of

                        Leber's Hereditary 

                   Optic Neuropathy 'LHON'



            A first statement:

            Leber's Hereditary Optic Neuropathy (LHON) is a mitochondrial disorder which is possibly due
            to mitochondrial mutations causing the enzyme COMPLEX I to be working at 50% of its normal capacity.

            A person who carried a LHON mutation may suffer from blindness as the enzyme COMPLEX I fails to provide
            enough 'energy' for the neurons in the optic nerves; but what might prevent this failure from happening,
            or what might precipitate this failure, remains unknown.




                                                Click to read the Introduction

Disclaimer: The author of these pages cannot be considered responsible for assumptions made by readers of these pages. So please be careful.

Ian Logan    Revised 27 January 2021