'ND4L' mutations and comparisons

The gene ND4L is one of the genes encode by mitochondrial DNA.
It is located at Bases 10470 - 10706.(All numbering is from CRS.)

Primate sequences:
                10470
NC_001807 Homo  MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC
Pan Paniscus    MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMTTLMTLNTHSLLANIVPITMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC
Pan troglodytes MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIVPITMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC
Gorilla gorilla MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHFLLANIVPITMLVFAACEAAVGLALLVSISNTYGLDYVQNLNLLQC
Pongo pygmaeus  MPLIYMNITLAFTMSLLGMLVYRSHLMSSLLCLEGMMLSLFIMITLMTLNTHSLLANIMPITMLVFAACEAAVGLALLASISNTYGLDYVNNLNLLQC
Pongo Abelii    MPLIYMNITLAFTMSLLGMLVYRSHLMSSLLCLEGMMLSLFIMITLMTLNTHSLLANIMPITMLVFAACEAAVGLALLASISNTYGLDYVNNLNLLQC
Hylobates lar   MPLIYMNITLAFAISLLGMLIYRSHLMSSLLCLEGMMLSLFIMSTLMALNTHSLLINIMPVVLLVFAACEAAVGLALLVSISNTYGLDHIHNLNLLQC
Macaca Sylvanus MTPTYMNIMLAFTISLLGMLTYRSHLMASLLCLEGMAMSLFIMTALIASNTHSPLINIMPIILLVFAACEAAVGLALLVSISNTYGLDYIHNLNLLQC
Macaca Mulatta  MTLTYMNIMLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMATLIASNTHFPLINIMPIILLVFAACETAVGLALLISISNTYGLDYVHNLNLLQC
Papio hamadryas MTPTHMNITLAFTISLLGMLIYRSHLMASLLCLEGMMMSLFIMTAVMASNAHSPLINIMPIIMLVFAACEAAVGLALLVSISNTYGLDHINNLSLLQC
Cercopithecus   MSPIFINITLAFTISLLGMLVYRSHLMASLLCLEGMMMSLFITIALMASNTHSPLINIMPITLLVFAACETAVGLALLVSISNTYGLDYIHNLNLLQC
Colobus Guereza MPIIYMNIMLAFTISLLGMLIYRSHLMSSLLCLEGMMLSLFIMNTLMALNMHSPLTNIVPITLLVFAACEAAVGLALLVSISSTYGLDHIQNLSLLQC
Trachypithecus  MPIIYMNIMLAFLISLLGMLFYRSHLMSSLLCLEGMMLSLFIMSTLMALNMHFPLANIVPIALLVFAACEAAVGLALLVSISNTYGLDYIHNLNLLQC
Cebus albifrons MPFIYINTALAYSMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMMTTMTLNMHLMLMYMLPIILLVFAACEAAVGLALLILISNLYGLDYVQNLNLLQC
Nycticebus      MPLISTNILLAFITALLGVLIYRSHLMSSLLCLEGMMLSMFILVSLTTMNLHFTLANIAPLILLVFAACEAAVGLALLVMVSNTYGMDYIQNLNLLQC
Lemur catta     MPSISTNIILAFITALLGMLIFRSHLMSSLLCLEGMMLSMFILSTLTILSLHFTTSFMMPILLLVFAACEAAVGLALLVTVSNTYGLDYIQNLNLLQC
Tarsius bancan. MPYIYTNLFLAFLTSLLGMLIYRSHLMSSLLCLEGMMLSMFIMTSLTILNLHFTLSNMIPIILLVFAACEAAVGLALLVMVSNTYGLDYVQNLNLLQC
Tupaia          MPSIYVNIMLAFATSLLGLLLFRSHLMSALLCLEGMMLSLFVLSSILVLNNHLILTAMLPIILLVFAACEAAVGLALLVMVSNTYGLDYVQNLNLLQC
Cynocephalus    MPPIYINIILAYTASLVGLLMYRSHFMSSLLCLEGMMLSLFILATILSLNLHFTLSFTLPIILLIFAGCETAVGLALLVMISDIYGLDHVQNLNLLQC

'Human' Mutations found in published genealogical sequences:-
CRS             MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC

A10506G          ACC>GCC thr>ala
AY882383(Yemen) MPLIYMNIMLAFAISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC
G10530A                  GTA>ATA val>met
DQ112706(Domin) MPLIYMNIMLAFTISLLGMLMYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC
T10609C                                            ATA>ACA met>thr
AY963572(Cambod)MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLTTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC
G10644A                                                        GTG>ATG val>met
mtDNA218(Asia)  MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIMPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC
C10654T                                                           GCC>GTC ala>val
KAsq0028(Japan) MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIVPIVMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC
A10750G                                                                                           AAC>AGC asn>ser
AY339567(Eur.)  MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLSLLQC



Amino acid table:
A .. ala    M .. met	
C .. cys    N .. asn
D .. asp    P .. pro
E .. glu    Q .. gln
F .. phe    R .. arg
G .. gly    S .. ser
H .. his    T .. thr
I .. ile    V .. val
K .. lys    W .. trp
L .. leu    Y .. tyr

Amino acid sequences are taken from NCBI. Note: In some instances I should be M.


More to come !

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2005